Approximate delirium prevalence among adults 65+ at hospital admission; community prevalence is much lower.
AAFP 2023
Acute confusion is a medical warning sign
Delirium is sudden brain failure until proven otherwise.
Delirium is an abrupt, fluctuating change in attention, awareness and thinking. It is common in older adults, after surgery, during severe infection, with medication toxicity or withdrawal, and in people living with dementia.
First hour mindset
Do the bedside basics while looking for the trigger.
- Confirm acute change: compare with baseline and collateral history.
- Stabilize ABCDE: oxygen, glucose, temperature, pain, hydration, safety.
- Screen delirium: 4AT on wards; CAM-ICU or ICDSC in ICU/recovery.
- Find reversible causes: infection, sepsis, drugs, withdrawal, metabolic, neurologic.
- Protect the brain: orientation, sleep, glasses/hearing aids, mobility, family presence.
Reported postoperative incidence range in older adults, varying by operation, acuity and assessment frequency.
POQI-6 consensusPooled adult ICU prevalence in a systematic review and meta-analysis; ventilated and high-severity groups may be higher.
Krewulak 2018Hypoactive delirium can look like sleepiness, withdrawal, depression or "just dementia".
NICE CG103Language safety
Aboriginal and Torres Strait Islander languages need interpreters, not guesswork.
Many Aboriginal and Torres Strait Islander patients speak English as a second, third or fourth language. For delirium, pain, consent, discharge planning and medicines, machine translation is not reliable enough. Use a professional Indigenous language interpreter whenever comprehension is uncertain.
Northern Territory
NT Government lists more than 100 Aboriginal languages and dialects. Widely spoken languages include Kriol, Yolngu Matha, Warlpiri, Pitjantjatjara, Murrinh-Patha, Anindilyakwa, Arrernte/Arrarnta, Kunwinjku, Burarra, Tiwi, Luritja/Pintupi, Gurindji, Maung, Alyawarr/Anmatyerr and Warumungu.
NT Aboriginal Interpreter Service language guideWestern Australia
Aboriginal Interpreting WA is the specialist Aboriginal language interpreting service across WA and works in more than 40 WA Aboriginal languages. WA Health resources also list Aboriginal English, Kriol, Kukatja, Martu Wangka/Wangkajunga, Miriwoong and other local language needs.
Aboriginal Interpreting WAQueensland
Queensland includes many Aboriginal languages, Torres Strait Islander languages and Indigenous sign languages. Queensland Indigenous Interpreting Service supports professional interpreting across Queensland, including the Torres Strait Islands.
Queensland Indigenous Interpreting ServiceClinical prompt
Ask: "What language do you speak at home?" and "Would you like an interpreter?" Do not use family for high-stakes interpreting unless there is an immediate emergency and no interpreter is available. Record the preferred language and interpreter need in handover.
National Indigenous Australians Agency interpreter servicesAotearoa New Zealand
Te reo Māori is included in the language selector for whole-page translation. For clinical decisions, consent, medicines and discharge planning, use a qualified interpreter where communication is uncertain and include whānau according to the patient's wishes.
New Zealand Ministry of Health Māori health resourcesPlain patient and family guide
What families can say, ask and watch for
Say this to staff
- This is not normal for them.
- They were last normal at this time.
- They usually know these people, places and routines.
- These medicines, alcohol use, falls, infections or pain changes are new.
Ask this
- Could this be delirium?
- Have oxygen, glucose, infection, pain, medicines, bladder and bowels been checked?
- Can we bring glasses, hearing aids, dentures, familiar objects and family support?
- What should make us call urgently tonight?
Watch at home or care home
- New confusion, sleepiness, fear, agitation, hallucinations or falls.
- Not eating or drinking, fever, cough, urine symptoms, constipation or pain.
- New tablets, missed tablets, sleeping tablets, opioid pain medicines or withdrawal.
- Stroke signs, seizure, severe drowsiness, breathing trouble or unsafe behavior need urgent help.
Patient and family section
What families notice first
Delirium usually develops over hours to days and changes during the day. The person may be alert one moment and drowsy, frightened, suspicious, restless or unusually quiet the next. A family member's description of "not their normal self" is often the clue that starts the diagnosis.
New confusion, marked drowsiness, agitation, fever, shortness of breath, chest pain, seizure, weakness on one side, head injury, overdose, or alcohol/benzodiazepine withdrawal symptoms should be treated as urgent until a clinician has assessed the cause.
Symptoms and signs
- Reduced attention: cannot follow conversation, distractible, loses track.
- Fluctuation: worse at night, after medications, during fever or dehydration.
- Disorganized thinking: rambling, odd beliefs, misreading the environment.
- Altered arousal: hyperactive, hypoactive, or mixed within the same day.
- Sleep-wake disruption, nightmares, hallucinations or misperceptions.
- New incontinence, falls, poor intake, reduced mobility or picking at lines.
Types and contexts
Delirium is one syndrome with many doors in.
Most patients have both vulnerability factors and one or more acute triggers. The practical question is not "which single cause?" but "which dangerous, reversible contributors are present today?"
Postoperative delirium
Common after major surgery, hip fracture, cardiac surgery and emergency operations. Risk rises with age, dementia, frailty, sensory impairment, infection, pain, sleep disruption, blood loss, ICU stay, urinary catheters, and deliriogenic medicines.
Drug-induced delirium
Anticholinergics, sedatives, opioids, corticosteroids, dopamine agonists, polypharmacy, renal failure with drug accumulation, and interactions are frequent causes. Medication review is a diagnostic test.
Delirium with dementia
Dementia is a major risk factor, but delirium is a new change from baseline. If uncertain, manage the delirium first, then reassess cognition after recovery.
Infection and sepsis
Pneumonia, urinary infection, cellulitis, abdominal sepsis, line infection, meningitis/encephalitis and COVID-like respiratory infections can present mainly as confusion in older adults.
ICU delirium
Ventilation, hypoxia, shock, sedatives, immobilization, sleep disruption, pain and critical illness inflammation make ICU delirium common and prognostically important.
Withdrawal states
Alcohol, benzodiazepine, barbiturate and some drug withdrawal syndromes can be life-threatening and need protocolized treatment, monitoring and thiamine where alcohol misuse or malnutrition is possible.
Infection is common, but not the only answer
Pneumonia, UTI and sepsis checks sit inside a broader delirium workup.
A positive urine test alone does not explain everything. The question is whether there is a true infection, organ dysfunction, hypoxia, drug effect, withdrawal, stroke, seizure, pain, retention or another concurrent trigger.
Clinician section
Diagnostic frame: acute attention failure plus a cause.
Use collateral history, baseline cognition/function, medication timing, observations and a structured bedside tool. Treat delirium as a medical emergency while avoiding over-investigation that ignores the bedside story.
Core diagnostic features
- Acute onset and fluctuating course.
- Inattention is central: months backwards, digit span, inability to track conversation.
- Disorganized thinking or altered level of consciousness.
- Evidence that the disturbance is caused by medical illness, substance, toxin or multiple causes.
Validated tools
- 4AT: rapid ward, emergency and long-term-care screening with a 0-12 score.
- CAM: classic diagnostic algorithm when staff are trained; not a severity score.
- CAM-ICU or ICDSC: ICU and post-anaesthesia recovery settings.
- Severity tracking: repeat screens, arousal scale, pain and function measures.
Phenotypes
- Hyperactive: agitation, pulling lines, fear, hallucinations.
- Hypoactive: quiet, slowed, withdrawn, reduced intake; high miss rate.
- Mixed: switches between restless and drowsy, often within hours.
Fillable bedside tools
Delirium scoring and diagnostic algorithms
These calculators are educational implementations of commonly used bedside tools. They support, but do not replace, trained clinical judgement, local policy, collateral history and urgent investigation of organic causes.
4AT
A rapid four-item screen. It gives a numeric score, but a positive result still requires clinical diagnosis and a search for the precipitating cause.
0: delirium or moderate-severe cognitive impairment is unlikely, but not excluded if clinical concern remains.
- 1-3 suggests possible cognitive impairment without clear delirium.
- 4 or more suggests possible delirium, with or without cognitive impairment.
- 4AT is designed to still score patients who are too drowsy or inattentive for cognitive tests.
CAM short algorithm
CAM is a diagnostic algorithm, not a severity scale. It is positive when features 1 and 2 are present, plus either feature 3 or feature 4.
CAM negative by the short algorithm. If clinical concern remains, repeat assessment and search for causes.
- Feature 1 needs a change from baseline or fluctuation, usually from collateral history or serial observation.
- Feature 2 means attention is impaired: distractible, cannot track questions, poor digit span or months backwards.
- CAM positivity does not grade severity; track severity separately with repeated assessments, arousal and function.
CAM-ICU
CAM-ICU adapts the CAM for critically ill or non-verbal patients. Assess arousal first. If the patient is not arousable enough to participate, document unable to assess rather than calling it negative.
CAM-ICU negative by algorithm. Feature 3 is generated from RASS: any RASS other than 0 counts as altered level of consciousness.
- Feature 3 is altered consciousness: RASS not equal to 0.
- Positive CAM-ICU: feature 1 plus feature 2 plus feature 3 or 4.
- RASS -4 or -5 is generally unable to assess for CAM-ICU.
ICDSC
The Intensive Care Delirium Screening Checklist scores eight features observed during the shift or preceding 8-24 hours. It is useful for repeated ICU screening and trend monitoring.
0: no delirium features documented during the observation period.
- 1-3 is often described as subsyndromal or possible delirium and should prompt reassessment.
- 4 or more is a positive ICDSC screen for delirium in many ICU protocols.
- Use alongside arousal assessment and clinical review of sedation, ventilation, sepsis and neurologic causes.
Nu-DESC
The Nursing Delirium Screening Scale is a rapid observation tool scored during a nursing shift. It tracks five visible delirium behaviors, each rated absent, mild or marked.
0: no Nu-DESC delirium behaviors documented during the observation period.
- 2 or more is commonly used as a positive Nu-DESC delirium screen.
- 1 may still justify repeat screening or adding an attention test, especially if concern is high.
- Nu-DESC is observational; it should be paired with baseline history and cause-finding.
Order of testing
A practical delirium investigation sequence
Adapt to acuity, local policy and the patient's goals of care. The safest order is: identify immediate danger, prove the syndrome, then test for common and dangerous causes in parallel.
Immediate bedside checks
Airway, breathing, circulation, disability, exposure. Vitals, oxygen saturation, temperature, capillary glucose, pain, hydration, urinary retention/constipation, falls or head injury, medication timing, alcohol/drug history, and current safety risk.
Mental status and baseline
Collateral history, baseline cognition and function, 4AT/CAM or CAM-ICU/ICDSC, arousal level, focal neurology, meningism, seizure activity, psychosis, suicidality, capacity and communication barriers.
Core tests for most acute presentations
CBC, electrolytes, renal/liver function, calcium, magnesium if relevant, glucose, CRP or other inflammatory marker by local practice, ECG before QT-prolonging drugs, urinalysis with culture only when symptoms/signs support UTI, medication levels where relevant.
Infection, hypoxia and sepsis screen
Chest exam and chest X-ray when respiratory signs, hypoxia or fever are present; blood cultures and lactate when sepsis is suspected; focused cultures from likely sites; review catheters, wounds, lines, abdomen, skin and meningitis/encephalitis features.
Medication, toxin and withdrawal review
Anticholinergic burden, sedatives, opioids, steroids, dopamine agonists, new antibiotics, recreational drugs, alcohol cessation, benzodiazepine withdrawal, renal dosing, interactions and recent anaesthetic exposure.
Neurologic escalation
Head CT or MRI when focal deficit, new seizure, reduced consciousness without explanation, head trauma, anticoagulation with fall, severe headache, suspected stroke/bleed, cancer, immunosuppression or failure to improve. EEG if non-convulsive seizure/status is plausible. Lumbar puncture if CNS infection/inflammation is suspected and imaging/bleeding risk are addressed.
Endocrine, nutritional and psychiatric contributors
TSH, B12, cortisol, ammonia, ABG/VBG, toxicology or other tests when the history fits. Depression, mania, psychosis and trauma can coexist, but a new fluctuating attention deficit should remain delirium until medical causes are treated.
Step-by-step management
Simple flow charts for acute and postoperative delirium
These are bedside logic maps. They do not replace local stroke, sepsis, shock, trauma, toxicology or surgical escalation pathways; they make sure those serious organic causes are actively excluded before settling into routine delirium care.
New acute confusion or agitation
-
Recognize acute change
Collateral baseline, onset over hours/days, fluctuating attention or arousal.
-
Immediate danger screen
ABCDE, vitals, oxygen saturation, glucose, temperature, pain, trauma, overdose, withdrawal risk.
-
Red flags present?
Stroke signs, seizure/status, meningism, head injury, shock, sepsis, hypoxia, hypoglycemia, severe intoxication.
-
If yes: activate emergency pathway
Stroke/sepsis/shock/trauma/toxicology care, senior review, imaging or resuscitation as indicated.
-
If no or after stabilization: confirm delirium
4AT or CAM; CAM-ICU/ICDSC if critically ill, ventilated or in recovery.
-
Find common reversible triggers
Medication burden, infection evidence, retention/constipation, dehydration, electrolytes, renal/liver failure, pain, sleep loss.
-
Start brain-protective care
Reorientation, calm observation, sensory aids, family presence, mobilization, hydration, sleep, remove unnecessary tethers.
-
Reassess frequently
Repeat vitals and mental status; if worsening or not improving, revisit red flags and broaden tests.
Confusion after surgery or anaesthesia
-
Do not dismiss as anaesthetic only
Check baseline cognition, operation, anaesthetic record, fluids, blood loss, analgesia and timing.
-
PACU or ward safety check
Airway, oxygenation, ventilation, BP, pulse, temperature, glucose, pain, bleeding, urine output.
-
Surgical or neurologic emergency?
Shock, sepsis, hypoxia, hemorrhage, stroke signs, seizure, malignant hyperthermia, PE, compartment or uncontrolled pain.
-
If yes: escalate immediately
Surgeon/anaesthetist/senior clinician review, resuscitation, imaging, labs and source control as indicated.
-
If stabilized: screen for delirium
CAM-ICU/ICDSC in PACU or ICU; 4AT/CAM on the ward; document arousal and fluctuation.
-
Remove postoperative triggers
Over-sedation, anticholinergics, benzodiazepines, excessive opioids, urinary catheter, retention, constipation, dehydration.
-
Recovery bundle
Analgesia without oversedation, early mobilization, nutrition, glasses/hearing aids, daylight, sleep protection, family orientation.
-
Plan discharge and prevention
Explain the episode, deprescribe where possible, flag future delirium risk and arrange cognition/function follow-up.
Treatment after stabilization
Once dangerous and reversible causes are treated, manage the delirium itself.
Delirium care is active treatment, not watchful waiting. The aim is to reduce distress, shorten exposure to triggers, prevent complications, maintain function and communicate clearly until the brain recovers.
1. Continue cause control
Recheck the original trigger and look for second hits: sepsis response, oxygenation, glucose, hydration, pain, retention, constipation, medication accumulation, sleep loss, bleeding, stroke/seizure red flags and withdrawal. Delirium often has more than one cause.
2. Build a calm brain environment
Daylight, clock/calendar, quiet nights, familiar objects, glasses/hearing aids, dentures, interpreter, repeated orientation and family presence. Explain every intervention before touching or moving the person.
3. Mobilize and detether
Sit out of bed, walk early when safe, remove unnecessary cannulas, catheters and monitors, avoid restraints where possible, prevent pressure injury and falls, and keep nutrition/hydration visible.
4. Treat distress without oversedation
Use verbal and non-verbal de-escalation first. Check pain, fear, toileting, hunger, breathlessness and sensory barriers. Hypoactive delirium may still involve frightening hallucinations or delusions.
5. Use drugs only for safety or severe distress
Antipsychotics do not fix delirium. Consider short-term use only when the person is severely distressed or risks harm and de-escalation is ineffective or inappropriate. Start low, review daily and stop as soon as possible.
6. Avoid making delirium last longer
Avoid benzodiazepines unless specifically indicated, such as alcohol/benzodiazepine withdrawal, seizures or catatonia. Avoid new anticholinergics, sedating antihistamines, unnecessary hypnotics and polypharmacy.
Daily delirium ward round
- What is the baseline, and is attention/arousal better, worse or fluctuating today?
- Which cause has been treated, and what second cause could still be active?
- Which medication can be stopped, reduced or dose-adjusted for renal/liver function?
- What is the mobility, sleep, hydration, pain, bowel and bladder plan for the next 24 hours?
- Who has updated family/care home, and what recovery/follow-up plan is documented?
Discharge and recovery
Document delirium clearly. Warn that recovery can take days to months, and that future admissions or operations carry higher risk. Arrange medication review, cognitive reassessment after recovery, mobility/function follow-up and care-home prevention instructions.
Drugs and alcohol
Medication review is both prevention and treatment.
Delirium can be caused by starting, stopping, accumulating or combining medicines. In older adults, anticholinergic load and sedative burden matter as much as any single named drug.
Common drug contributors
- Anticholinergics: atropine-like effects, bladder antimuscarinics, tricyclics, antihistamines.
- Benzodiazepines, Z-drugs, barbiturates and sedating antihistamines.
- Opioids, especially high dose, renal accumulation, or combined sedatives.
- Corticosteroids, dopamine agonists, anticonvulsants, lithium, digoxin toxicity.
- Some antimicrobials and antivirals, especially with renal impairment or CNS vulnerability.
Reversal and specific antidotes
- Glucose for hypoglycemia; treat immediately.
- Naloxone for clinically significant opioid toxicity with respiratory depression.
- Thiamine when alcohol misuse, malnutrition or Wernicke risk is possible.
- Flumazenil only in carefully selected benzodiazepine toxicity; seizure risk can be serious.
- Physostigmine is a toxicology/critical-care decision for severe anticholinergic toxicity, not routine delirium treatment.
Usually avoid or minimize
- New sedatives for "sleep" during delirium.
- Antipsychotics for prevention or to hasten delirium resolution.
- Benzodiazepines unless treating alcohol/benzodiazepine withdrawal, seizures, catatonia, or another specific indication.
- Physical restraints when observation, family presence, de-escalation and environmental changes can reduce risk.
Postoperative delirium
Prevent before the operation, detect early after it.
Preoperative risk recognition, sensory aids, medication simplification, pain control, hydration, avoiding unnecessary tethers, early mobilization and sleep protection are the backbone. After surgery, do not assume confusion is "just anaesthetic"; assess for hypoxia, sepsis, bleeding, retention, pain, stroke and drugs.
High-risk settings
Hip fracture, pre-surgical screening and home detection
Hip fracture, frailty, dementia and preoperative cognitive impairment sharply increase delirium risk. The practical response is early recognition, prevention bundles, and clear communication between family, care homes, general practice, ambulance services and hospitals.
Hip fracture
Treat every older hip-fracture patient as high risk. Start orientation, hydration, analgesia without oversedation, oxygenation, bowel/bladder care, medication review, early orthogeriatric input and mobilization planning as soon as feasible.
Pre-surgical cognitive screen
Ask about baseline memory, function, prior delirium and care-home residence. Consider Mini-Cog, MoCA, AMT4/4AT or local geriatric-surgery screening; a low screen should trigger prevention planning, not automatic cancellation.
Nursing-home and care-home patients
Avoid reflex hospital transfer when the person is stable and assessment can be done safely in place. Send baseline cognition, medication changes, observations, hydration/intake, falls, infection signs and family concerns with any escalation.
When hospital is needed
New focal weakness, seizure, head injury, severe pain, hypoxia, shock, sepsis features, chest pain, dangerous agitation, overdose, withdrawal, inability to maintain hydration, or unsafe care at home needs urgent clinical escalation.
Family and care-home tool
Adapted home delirium check
This is a CHAMEOS+-inspired checklist, adapted for this website because I could not verify a canonical published CHAMEOS+ version. Use it as a practical prompt to detect new or worsening delirium and to find reversible contributors; use Family CAM or local tools when a validated family screen is needed.
No home-check areas selected. Keep watching for sudden change, especially in dementia, infection, dehydration, after falls or after medication changes.
Prediction and prevention
The best delirium treatment is a prevention plan started early.
Risk tools differ by setting, but the same prevention domains repeatedly appear in guidelines and trials: orientation, mobility, hydration, nutrition, sleep, sensory aids, pain control, medication review and early treatment of acute illness.
Bedside risk helper
Select risk factors present now. This is not a diagnostic score; it helps prompt prevention.
Prevention bundle
Action plans
What to do by situation
Family or carer plan
- Tell staff the person's normal memory, mobility, personality, hearing and vision.
- Report the time course: exactly when confusion, sleepiness, agitation or hallucinations started.
- Bring medication lists, alcohol history if relevant, glasses, hearing aids and dentures.
- Use short calm sentences; remind the person where they are and that they are safe.
- Ask what cause is being treated and what prevention bundle is in place.
Medical ward plan
- Screen daily if at risk or if any change occurs; document baseline and fluctuation.
- Run bedside stabilization and core tests; treat sepsis, hypoxia, glucose and pain promptly.
- Review medication burden before adding sedatives.
- Use de-escalation, observation and environmental care before antipsychotics.
- Escalate imaging, EEG, LP or specialty review when neurologic red flags or non-resolution appear.
ICU plan
- Assess sedation/arousal first, then CAM-ICU or ICDSC.
- Minimize benzodiazepines unless specifically indicated; target light sedation where possible.
- Use ABCDEF-style care: analgesia, awakening/breathing coordination, sedation choice, delirium monitoring, early mobility, family engagement.
- Consider dexmedetomidine strategies in appropriate ventilated patients according to local ICU guidance.
- Plan liberation from ventilation, lines, immobility and sleep disruption as clinical status allows.
Postoperative plan
- Pre-op: identify high risk and document baseline cognition, function and sensory needs.
- Intra/post-op: avoid unnecessary deliriogenic medicines and oversedation; optimize pain and oxygenation.
- Recovery room: use CAM-ICU/ICDSC when appropriate; check hypoxia, hypotension, bleeding, glucose and retention.
- Ward: mobilize early, restore sleep, remove catheters and reintroduce normal aids/routine.
- Discharge: explain delirium episode, medication changes, recurrence prevention and cognitive follow-up.
Causes checklist
Think in overlapping buckets
Oxygen and perfusion
Hypoxia, hypercapnia, shock, anaemia, myocardial infarction, arrhythmia, pulmonary embolism.
Infection and inflammation
Pneumonia, UTI with true symptoms/signs, sepsis, cellulitis, abdominal source, CNS infection, COVID-like illness.
Metabolic
Hypo/hyperglycemia, sodium, calcium, renal/liver failure, dehydration, acid-base disorder, endocrine crisis.
Neurologic
Stroke, bleed, head injury, seizure, non-convulsive status, tumour, CNS infection, hypertensive encephalopathy.
Medication and toxin
Anticholinergic burden, sedatives, opioids, steroids, drug interactions, renal accumulation, intoxication.
Withdrawal
Alcohol, benzodiazepines, barbiturates, opioids and other substance withdrawal syndromes.
Environment and function
Sleep deprivation, sensory deprivation, immobilization, catheters, restraints, pain, unfamiliar surroundings.
Psychiatric overlap
Depression, mania, psychosis, trauma and catatonia can mimic or compound delirium, but do not exclude medical causes.
Recovery
Delirium can fade, but follow-up matters.
Some people recover quickly; others have weeks to months of sleep disturbance, fear, poor concentration or reduced function. Document the episode, deprescribe where possible, screen cognition after recovery, and warn future surgical or hospital teams that delirium risk is higher next time.
Evidence base
Selected reputable references
This educational site summarizes guideline and review evidence; it is not a substitute for local clinical protocols, emergency assessment or specialist advice.